松阳洲，男，中山大学生命科学学院院长，教授，博士导师。 美国Baylor医学院生化和分子生物承绿结尽学系终身教授，分子来自药物研发主任，RNAi 中心主任，Huf360百科fington 衰老和细胞露分子生物学中心，干细胞和新生医学中心及Dan L. Duncan肿瘤中心研究员。在过去的十离停顺火各粮基团多年，松阳教授在分子细胞学领域的研究中做出了独创性的贡献。他对人体细胞端粒调节机理和胚胎干细胞的蛋白组学和功能性的研究处于国内外相关领域的前沿。

• 中文名称 松阳洲
• 国籍 中国
• 职业 教授、科学家
• 毕业院校 中山大学，美国波士顿塔夫兹大学

研究方向

　　干料首百测满适卫座细胞生长与分化， 肿瘤生长和人体衰老机制; 细胞端粒的结构、端粒蛋白的功能与作用机理，信号传导网络，DNA 损伤与修复，蛋白质间相互来自作用以及功能基因的高通量筛选360百科和鉴定。

简历

　　1990年获广玉未布护善你呀且首夫足州中山大学生物化学理学学士学位，1层草曲五析布995年获美国波士简啊教缩光顿塔夫兹大学生命医通资剂学学院分子和细胞生理学博士学位， 1995年到1998年先后在哈佛大学医学院细胞生物学系和麻省理工学院(MIT)生物系做博士后工作。1998年在美国贝勒医学院生化和分子生物学系任助理教授。2004年晋升为终身副教授，2008年晋升为生化和分子若福非坚消买族庆生物学系终身教授。同时担任贝勒医学院药学强永引减整将斗曾式系教授，高通量实验中心主任，家那亲造甲于坚础烧兼Huffington衰老和细胞分子生物学中心，干细胞和新生医学中心及D.L. Duncan密步所食总毫钟引肿瘤中心研究员。2009年就任中山大学生命科学学院院长。

　　已发表论文和论著达80篇，在Nature, Science, Cell, PNAS, Natur病适远草e Cell Biology, NSMB, Molecula跳r Cell等影响因子大于10的期刊上发表论文逾20篇;总引用次数超过7500次。

荣誉

　　曾荣获Scienti聚积济多分责st报年度最佳论文奖和Cell促头构元所简宗杂志30年最佳30篇文章奖，Irvington Institute Postdoctoral Fellowship, Ellison New Scholar，American Cancer Society Scholar与Leukemia and Lymphoma Society Scholar等荣誉。担任Science, Nature, Cell, P来自NAS和JBC等国际刊物的审稿人。

代表性的论文

　　(选360百科自70多篇SCI文章)

　　1. Songyang, Z., Shoelson, SE, Chad更府脸行指huri, M., Gish, G., Pawson, T社., Haser, WG, King, F., Roberts阶程执尽皇每后, T., Ratnofsky, S., Lechleider, RJ, Neel, BG, Birge, RB线稳情林合伟原棉打, Fajardo JE, Chou, MM, Hanafus映司者停越械龙很任利a, H., Schaffhausen, B. and Cantley, LC (1993) SH2 Domains Recognize Specific Phosphopeptide Sequences. Cell 72, 767-778. (Cell杂志30年最佳30篇文章之一)

　　2. Ravichandran KS, Lee KK, Songyang Z., Cant有况ley LC, Burn P预血买里续被同, Burakof范f SJ (1993) Interaction of Shc with the zeta chain of the T cell receptor upon T cell act土离突错选坐格步飞ivation. Science. 262:902-5.

　　3. Songyang, Z., Sh甲务南转军温妈坚oelson, SE, McGlade, Olivier, JP, Pawson, T., Bustelo, XR, Barbacid, M., Sabe, H., Hanafusa, H., Yi, T., Ren, R., Baltimore, D., Ratnofsky, S., Feldman, RA, and Cantley, LC (1994) Specific Motifs Recogni策江基唱双谓革zed by the SH2 Domains of Csk, 3晶顾药技BP2, fps/fes, GRB-2, SHPTP1, SHC, Syk and Vav. Mol. Cell. Bi的互婷画图甲ol.14, 2777-2785. (Scientist报年度最佳论文奖)

　　4. Marengere, LE, Songyang, Z., Gish, GD, Sch含二右话着进阳各aller, MD, Parsons, JT, Stern, MJ, Cantley, LC, a促父主调管nd Pawson, T. 伤跳种赵翻降(1994) SH2 domain specificity and activity modified by a single residue. Nature 369, 502-505.

　　5. Songyang, Z., Blechner, S., Hoagland, N., Hoekstra, M. F., Piwnica-Worms, H., Cantley, L. C. (1994) Use of an oriented peptide library technique for determining the optimal substrates of protein kinases. Curr. Biol. 4, 973-982.

　　6. Songyang, Z., Carraway, KL III, Eck, MJ, Harrison, SC, Feldman, RA, Mohammodi, M., Schlessinger, J., Hubbard, S., Smith, DP, Eng, C., Lorenzo, M. J., Ponder, BAJ., Mayer, BJ, and Cantley, LC (1995) Catalytic specificity of protein-tyrosine kinases is critical for selective signaling. Nature 373, 536-539.

　　7. Songyang, Z., Lu, KP, Kwon, YT, Tsai, LH, Filhol, O., Cochet, C., Brickey, D. A., Soderling, TR, Bartleson, C., Graves, DJ, DeMaggio, AJ, Hoekstra, M. F., Blenis, J., Hunter, T., and Cantley, LC (1996) A structural basis for substrate specificities of protein Ser/Thr kinases: Primary sequence preference of casein kinases I and II, NIMA, phosphorylase kinase, calmodulin-dependent kinase II, CDK5, and Erk1. Mol. Cell. Biol. 16, 6486-6493.

　　8. Songyang, Z., Fanning, AS, Fu, C., Xu, J., Marfatia, SM, Chishti, AH, Crompton, A., Chan, AC, Anderson, JM, and Cantley, LC (1997) Recognition of unique carboxyl-terminal motifs by distinct PDZ domains. Science 275, 73-77.

　　9. Songyang, Z., Baltimore, D., Cantley, L. C., Kaplan, D. R., and Franke, T. F. (1997) Interleukin 3-dependent survival by the Akt protein kinase. PNAS 94, 11345-11350.

　　10. Liu, D., Yang, X. H., and Songyang, Z. (2000) Identification of CISK, a new member of the SGK kinase family that promotes IL-3 dependent survival. Curr. Biol. 10, 1233-36.

　　11. Liu, D., Yang, X. H., Yang, D. L., and Songyang, Z. (2000) Genetic screens in mammalian cells using Enhanced Retroviral Mutagens. Oncogene, 19, 5964-72.

　　12. Songyang, Z., Yamanashi ,Y., Liu, D., and Baltimore, D. (2001) Domain-dependent function of p62Dok in cell signaling. J. Biol. Chem. 276, 2459-65.

　　13. Xu, J., Liu, D., Gill, G., and Songyang, Z. (2001) Regulation of cytokine-independent survival kinase (CISK) by the Phox homology domain and phosphoinositides. J. Cell. Biol. 154, 699-706

　　14. Xu, J., Liu, D., Songyang, Z. (2002) The role of asp-462 in regulating akt activity. J Biol Chem. 277:35561-6.

　　15. Rodriguez M, Yu X, Chen J, and Songyang Z. (2003) Phosphopeptide binding specificities of BRCT domains. J Biol Chem. 278: 52914-8.

　　16. Rodriguez M, Li, SC, Harper JW, and Songyang Z. (2004) An oriented peptide array library (OPAL) strategy to study protein-protein interactions. J Biol Chem. 279:8802-7.

　　17. Songyang Z. and Cantley LC (2004) ZIP codes for delivering SH2 domains. Cell. 116:S41-3.

　　18. OConnor MS, Safari A, Liu D, Qin J, and Songyang Z. (2004) The human Rap1 protein complex and modulation of telomere length. J Biol. Chem. 279(27):28585-91.

　　19. Liu D, Safari A, O'Connor MS, Chan DW, Laegeler A, Qin J, Songyang Z. (2004) PTOP interacts with POT1 and regulates POT1 telomeric localization. Nature Cell Biol. 6(7):673-80.

　　20. Liu D, O'Connor MS, Qin J, Songyang Z. (2004) Telosome, a mammalian telomere-associated complex formed by multiple telomeric proteins. J Biol. Chem. 279:51338-42.

　　21. O'Connor MS, Safari A, Xin H, Liu D, Songyang Z. (2006) A critical role for TPP1 and TIN2 interaction in high-order telomeric complex assembly. PNAS. 103:11874-9.

　　22. Xin H, Liu D, Safari A, Wan M., Sun W, Kim H, O'Connor MW, and Songyang Z. (2007) TPP1 is a homologue of ciliate TEBP-beta and interacts with POT1 to recruit telomerase. Nature45, 559-62.

　　23. Chen L., D. Liu, and Songyang Z. (2007) Telomere maintenance through spatial control of telomeric proteins. Mol. Cell Biol. 27: 5898-909.

　　24. Liang JC, Ma W., Zhang Y., Gu P., Xin H., Jung SY, Qin J., Wong J., Cooney A., Liu D., and Songyang Z. (2008) Nanog and Oct4 associate with unique transcriptional repression complexes in embryonic stem cells. Nature Cell Biol. 10:731-9.

　　25. Dejosez M, Krumenacker JS, Zitur LJ, Passeri M, Chu LF, Songyang Z., Thomson JA, Zwaka TP. (2008) Ronin is essential for embryogenesis and the pluripotency of mouse embryonic stem cells. Cell 133:1162-74.

　　26. Kim H., LeeOH, XinH., ChenLY, QinJ., ChaeHK, LinSY, SafariA., LiuD., and Songyang Z. (2009) TRF2 functions as a protein hub and regulates telomere maintenance by recognizing specific peptide motifs. Nature Struc. Mol. Biol. 16: 372-379.