汤亚杰么伟卫审助夜即于2005年从美国麻省理工学院(MIT)学成回国洲胶什构跳叶少永，现任山东大学特聘教授另毫调机操冷们、博士生/硕士生导师。 2020年5月起任山东大学青岛校区党工委委员、副校长。

主要从事"发酵工程"领域的教学科研工作，聚集天然产物生物制造，致力来自于解决实验室的生物技术成果产业化的瓶颈问题360百科。应邀出任发酵工程领域学术期刊"Bioprocess and Biosystems Engineering (Springer)"Associate Editor (副主编)。先后入选全国杰出专业技术人才、"万人计划"科技创新领军人才、"新世纪百千万人才工程"国家级人选、国家杰出青年科学基金获得者。

• 中文名称 汤亚杰
• 国籍 中国
• 民族 汉族
• 出生日期 1973年10月
• 出生地 湖北省武穴市

研究兴趣

　起露斗名下调广局专　以国家战略需求产品抗肿瘤药物为导向，致力于生来自物化工领域天然产物生物制造的研究。以具有良好抗肿瘤活性的天然产物为目标，采用合成生物学的思路，高效制备具有成药前景的药物前体，并深入理解天然产物人工合成的调控机制，为天然产物生物制造提供新思路、新理论和新方法。

学术奖励

　　1. 湖北省科技进步一等奖(2014)

　　2. 教育部自然科学一等奖(2014)

　　3. 湖北省自然科学二等奖(2011)

　　4. 上海市自然科学二等奖(2010)

360百科　　5. 教育部自然科学一等奖(2004)

　　6.湖北省自然科学一等奖(2016)

学术荣誉

　　1. 全国杰出专仍位止深显业技术人才(2014)

　　2. "万人计划"科技创新领军人才(2014)

　来自　3. "新世纪百千万人才工程"国家级人选(2009)

学术兼职

　　1. 360百科Associat命粉e Editor: B散请ioprocess 逐城有矛美and Biosystems Engineering (Springer) (2012-)

　　2. Advisory Board: Biotechnology Journal (Wiley)(2012-)

　　3.湖北省食品质量安全抽检监测专家委员会·副主任委员 (2014-)

发明专利

　　1.Ya-Jie Tang. 4′-Demthylepipodophyllotoxin Derivative, Preparation Method and Use There最陈of (US 8569309B2)

　　2. Ya-Jie Tang, We站预进哥同歌细块原i Zhao. 4′-Demthylepipod求手论友优ophyllotoxin Derivative, Preparation Method and Use Thereof II (US 8796279B2)

　　3. 汤亚杰 李冬生 孔国平. 一种块菌多糖的制备方法 (ZL200610166504.6)

　　4. 汤亚杰 王冠 刘瑞桑 李冬生. α-雄烷醇的制备及含量游安情统检测方法 (ZL20广081000057也基环缩自略0.5)

　　5. 汤亚杰 李冬生 朱丽雯. 促进灵芝次生代谢产物合成的细胞培养方法 (ZL 200810001055.9)

　　6. 汤亚杰 张伟 李冬生. 一种促进灵芝酸和灵芝多眼都演掌糖生物合成的灵芝细胞培养方法(ZL200810002药算养鲜鱼修772.3)

　　7. 汤亚加术娘任杰 徐小玲 李冬生. 4′-去甲基表鬼臼酸的制备和分离方法 (ZL200810002大菜773.8)

　　8. 汤亚杰 李艳 李状始因绝州根议委安冬生. 将鬼臼毒素转化为鬼臼酸和鬼臼苦素的在宗则包方法 (ZL2008100江控期02774.2)

　　9. 汤亚杰 张伟. 促进灵芝酸和灵芝多糖生物合成的发酵方法(ZL 200810007833.5)

　　10. 汤亚杰 柳巧宁. 中间补料发酵生产块菌活性菌丝体和块菌多糖的方法 (ZL 200810172343.0)

　　11. 汤亚杰 李园园. 具抗电否难棉肿瘤活性的羊毛甾烷型三萜化合物及制备方法和应用(ZL 200810184588.5)

　　12. 汤亚杰, 赵巍. 4′-去甲基表鬼臼毒素衍生物及其合成方法和应用. (ZL 201010156798.0)

　　13.汤亚杰,赵巍.4′-去甲基表鬼臼毒素衍生物及其合成方法和应用.(PCT/2010/CN/8569309)

　　14. 汤亚杰, 赵巍. 4-(2,3,5,6-四甲基吡嗪-1-基)-4′-去甲表鬼臼毒素的生物转化及分离纯化方法. (ZL 201010159753.9)

　　15. 汤亚杰 李园园. 脑苷脂的制备、纯化及含量检测方法 (ZL 201010268280.6)

　　16. 汤亚杰 白佳珂. 硫取代鬼臼类衍生物及其合成方法和应用 (ZL 201110106180.8)

　　17. 汤亚杰 白佳珂. 硫取代鬼臼类衍生物及其生物转化和分离纯化方法 (ZL 201110106192.0)

　　18. 汤亚杰 肖黎. 具有抗肿瘤活性的酯化鬼臼类衍生物及其制备方法和用途(ZL201210374710.1)

　　19. 汤亚杰 肖黎. 具抗肿瘤活性的氮取代鬼臼类衍生物及其制备方法和用途(ZL 201210374359.6)

　　20.汤亚杰 陈露 赵巍. 具抗肿瘤活性的酰胺取代鬼臼类衍生物及其制备方法和用途(ZL201310292277.1)

代表性论文

　　1. Ya-Xuan Zhang, Wei Zhao, Ya-Jie Tang*. Multilevel induction of apoptosis by microtubule-interfering inhibitors 4β-S-aromatic heterocyclic podophyllum derivatives causing multi-fold mitochondrial depolarzation and PKA signaling pathways in HeLa cells.Oncotarget (In press) 2016 (IF=6.359) ( with equal contribution to this work)

　　2. Jun-Han Yu, Li-Wen Zhu, Shi-Tao Xia, Hong-Mei Li, Ya-Ling Tang, Xin-Hua Liang, Tao Chen, Ya-Jie Tang*. Combinatorial optimization of CO2 transport and fixation to improve succinate production by promoter engineering. Biotechnology and Bioengineering (In press) 2016 ( with equal contribution to this work)

　　3. Kai-Zhi Jia, Quan Zhang, Lin-Yang Sun, Yang-Hua Xu, Hong-Mei Li, Ya-Jie Tang*. Clonostachys rosea demethiolase STR3 controls the conversion of methionine into methanethiol. Scientific Reports 2016, 6:21920 (IF=5.578)

　　4. Quan Zhang, Kai-Zhi Jia, Shi-Tao Xia, Yang-Hua Xu, Rui-Sang Liu, Hong-Mei Li, Ya-Jie Tang*. Regulating ehrlich and demethiolation pathways for alcohols production by the expression of ubiquitin-protein ligase gene HUWE1. Scientific Reports 2016, 6:20828 ( with equal contribution to this work)

　　5. Rui-Sang Liu, Guang-Huai Jin, Deng-Rong Xiao, Hong-Mei Li, Feng-Wu Bai*, Ya-Jie Tang*. Screening of the key volatile organic compounds of Tuber melanosporum fermentation by aroma sensory evaluation combination with principle component analysis. Scientific Reports 2015, 5:17954. ( with equal contribution to this work)

　　6. Li-Wen Zhu, Lei Zhang, Li-Na Wei, Hong-Mei Li, Zhan-Peng Yuan, Tao Chen, Ya-Ling Tang, Xin-Hua Liang, Ya-Jie Tang*. Collaborative regulation of CO2 transport and fixation during succinate production in Escherichia coli. Scientific Reports 2015, 5:17321 ( with equal contribution to this work)

　　7. Deng-Rong Xiao, Rui-Sang Liu, Long He, Hong-Mei Li, Ya-Ling Tang, Xin-Hua Liang, Tao Chen, Ya-Jie Tang*. Aroma improvement by repeated freeze-thawed treatment during Tuber melanosporum fermentation. Scientific Reports 2015, 5:17120 ( with equal contribution to this work)

　　8. Wei Zhao, Yong Yang, Ya-Xuan Zhang, Hong-Mei Li, and Ya-Jie Tang*. Fluoride-containing podophyllum derivatives exhibit antitumor activities through enhancing mitochondrial apoptosis pathway by increasing the expression of caspase-9 in HeLa cells. Scientific Reports 2015, 5:17175 ( with equal contribution to this work)

　　9. Jian-Long Li, Wei Zhao, Chen Zhou, Ya-Xuan Zhang, Hong-Mei Li, Ya-Ling Tang, Xin-Hua Liang, Tao Chen, Ya-Jie Tang*. Comparison of carbon-sulfur and carbon-amine bond in therapeutic drug: 4β-S-aromatic heterocyclic podophyllum derivatives display antitumor activity. Scientific Reports 2015, 5:14814 ( with equal contribution to this work)

　　10. Wei Zhao, Jia-Ke Bai, Hong-Mei Li, Tao Chen, Ya-Jie Tang*. Tubulin structure-based drug design for the development of novel 4β-sulfur-substituted podophyllum tubulin inhibitors with anti-tumor activity. Scientific Reports 2015, 5:10172.

　　11. Ya-Jie Tang*, Rui-Sang Liu, Hong-Mei Li. Current progress on Tuber submerged fermentation: a promising alternative for its fruiting bodies. Applied Microbiology and Biotechnology 2015, 99: 2041-2053. ( with equal contribution to this work)

　　12. Li Xiao, Wei Zhao, Hong-Mei Li, Duan-Ji Wan, Dong-Sheng Li, Tao Chen, Ya-Jie Tang*. Design and synthesis of the novel DNA topoisomerase II inhibitors: esterification and amination substituted 4′-demethylepipodophyllotoxin derivates with anti-tumor activity by activating ATM/ATR signaling pathways.European Journal of Medicinal Chemistry 2014, 80: 267-277. ( with equal contribution to this work)

　　13. Wei Zhao, Xiao-Hua Wang, Hong-Mei Li, Shi-Hua Wang, Tao Chen, Zhan-Peng Yuan, Ya-Jie Tang*. Isolation and characterization of polysaccharides with the anti-tumor activity fromTuber fruiting bodies and fermentation system. Applied Microbiology and Biotechnology 2014, 98:1991-2002. ( with equal contribution to this work)

　　14. Wei Zhao, Lu Chen, Hong-Mei Li, Duan-Ji Wan, Dong-Sheng Li, Tao Chen, Zhan-Peng Yuan*, Ya-Jie Tang*. A rational design strategy of the novel topoisomerase II inhibitors for the synthesis of the 4-O-(2-pyrazinecarboxylic)-4′-demethylepipodophyllotoxin with antitumor activity by diminishing the relaxation reaction of topoisomerase II-DNA decatenation. Bioorganic & Medicinal Chemistry 2014, 22:2998-3007. ( with equal contribution to this work)

　　15. Huai Wang, Li-Jun Tang, Ya-Jie Tang*, Zhan-Peng Yuan*. SAR analysis and biological studies of synthesized podophyllum derivates obtained by N linkage modification at C-4 position. Bioorganic & Medicinal Chemistry 2014, 22: 6183-6192.

　　16. Wei Zhao, Dan-Dan Chai, Hong-Mei Li, Tao Chen, Ya-Jie Tang*. Significance of metal ion supplementation in the fermentation medium on the structure and anti-tumor activity of Tuber polysaccharides produced by Tuber submerged fermentation. Process Biochemistry 2014, 49: 2030-2038. ( with equal contribution to this work)

　　17. Dao-Cheng Li, Rui-sang Liu, Hong-Mei Li, Zhan-Peng Yuan, Tao Chen, Ya-Jie Tang*. Ranking the significance of fermentation condition on the volatile organic compounds of Tuber melanosporum fermentation system by combination of head-space solid phase microextraction and chromatographic fingerprint similarity analysis. Bioprocess and Biosystems Engineering 2014, 37(3):543-552.

　　18. Li-Wen Zhu, Xiao-Hong Li, Lei Zhang, Hong-Mei Li, Jian-Hua Liu, Zhan-Peng Yuan, Tao Chen, Ya-Jie Tang*. Activation of glyoxylate pathway without the activation of its related gene in succinate-producing engineered Escherichia coli. Metabolic Engineering 2013, 20:9-19. ( with equal contribution to this work)

　　19. Rui-Sang Liu, Huan Zhou, Hong-Mei Li, Zhan-Peng Yuan, Tao Chen, Ya-Jie Tang*. Metabolism of L-methionine linked to the biosynthesis of volatile organic sulfur-containing compounds during the submerged fermentation of Tuber melanosporum.Applied Microbiology and Biotechnology 2013, 97:9981-9992. ( with equal contribution to this work)

　　20. Yuan-Yuan Li, Ping Liu, Yang Tang, Hong-Mei Li, Ya-Ling Tang, Xin-Hua Liang, Ya-Jie Tang*. Novel cerebrosides isolated from the fermentation mycelia of Tuber indicum.Helvetica Chimica Acta 2013, 96:702-709.

　　21. Jia-Ke Bai, Wei Zhao, Hong-Mei Li, Ya-Jie Tang*. Novel biotransformation process of podophyllotoxin to 4β-sulfur-substituted podophyllum derivates with anti-tumor activity by Penicillium purpurogenum Y.J. Tang. Current Medicinal Chemistry 2012, 19:927-936.

　　22. Rui-Sang Liu, Dao-Cheng Li, Hong-Mei Li, Ya-Jie Tang*. Evaluation of aroma active compounds in Tuber fruiting bodies by gas chromatography-olfactometry in combination with aroma reconstitution and omission test. Applied Microbiology and Biotechnology 2012, 94:353-363.

　　23. Wei Zhao, Hong-Mei Li, Duan-Ji Wan, Ya-Jie Tang*. Manipulation of heterogeneity product in 4′-demethylepipodophyllotoxin biotransformation process by using yeast extract as nitrogen source. Applied Microbiology and Biotechnology 2012, 93:107-115.

　　24. Yuan-Yuan Li, Guan Wang, Hong-Mei Li, Jian-Jiang Zhong, Ya-Jie Tang*. Volatile organic compounds from Tuber melanosporum fermentation system. Food Chemistry 2012, 135:2628-2637.

　　25. Ping Liu, Hong-Mei Li, Ya-Jie Tang*. Comparison of free amino acids and 5'-nucleotides between Tuber fermentation mycelia and natural fruiting bodies.Food Chemistry 2012,132:1413-1419.

　　26. Yang Tang, Hong-Mei Li, Ya-Jie Tang*. Comparison of sterol composition between Tuber fermentation mycelia and natural fruiting bodies.Food Chemistry 2012,132:1207-1213.

　　27. Li-Wen Zhu, Cheng-Cheng Wang, Rui-Sang Liu, Hong-Mei Li, Duan-Ji Wan, Ya-Jie Tang*. Actinobacillus succinogenes ATCC 55618 fermentation medium optimization for the production of succinic acid by response surface methodology. BioMed Research International Volume2012, Article ID626137, 9 pages doi:10.1155/2012/626137.

　　28. Wei Zhao, Hong-Mei Li, Ya-Ling Tang, Xin-Hua Liang, Duan-Ji Wan, Ya-Jie Tang*. Optimization of a biotransformation process to produce 4-(2, 3, 5, 6-tetramethylpyrazine-1)-4′-demethylepipodophyllotoxin. Process Biochemistry 2012, 47:1522-1531.

　　29. Ya-Jie Tang*, Guan Wang, Yuan-Yuan Li, Hong-Mei Li, Yang Tang, Ping Liu. Quantitative determination for the major volatile organic compounds of Tuber melanosporum fermentation system by distillation-solid phase extraction-gas chromatography.Food Analytical Methods 2012,5:651-658.

　　30. Xiu-Ji Liu, Rui-Sang Liu, Hong-Mei Li, Ya-Jie Tang*. Lycopene production from synthetic medium by Blakeslea trispora NRRL 2895 (+) and 2896 (-) in a stirred-tank fermenter. Bioprocess and Biosystems Engineering 2012, 35:729-749.

　　31. Jin-Feng Wang, Xiu-Ji Liu, Rui-Sang Liu, Hong-Mei Li, Ya-Jie Tang*. Optimization of the mated fermentation process for the production of lycopene by Blakeslea trispora NRRL 2895 (+) and NRRL 2896 (-). Bioprocess and Biosystems Engineering 2012, 35:553-564.

　　32. Cheng-Cheng Wang, Li-Wen Zhu, Hong-Mei Li, Ya-Jie Tang*. Performance analyses of a neutralizing agent combination strategy for the production of succinic acid by Actinobacillus succinogenes ATCC 55618. Bioprocess and Biosystems Engineering 2012, 35:659-664.

　　33. Ping Liu, Yuan-Yuan Li, Hong-Mei Li, Duan-Ji Wan, Ya-Jie Tang*. Determination of the nucleosides and nucleobases in Tuber samples by dispersive solid-phase extraction combined with liquid chromatography–mass spectrometry. Analytica Chimica Acta 2011, 687:159-167.

　　34. Ya-Jie Tang*, Wei Zhao, Hong-Mei Li. Novel tandem biotransformation process for the biosynthesis of a novel compound 4-(2, 3, 5, 6-tetramethylpyrazine-1)-4′-demethylepipodophyllotoxin. Applied and Environmental Microbiology 2011, 77:3023-3034.

　　35. Wei Zou, Li-Wen Zhu, Hong-Mei Li, Ya-Jie Tang*. Significance of CO2 donor on the production of succinic acid by Actinobacillus succinogenes ATCC 55618. Microbial Cell Factories 2011, 10:87.

　　36. Yang Tang, Yuan-Yuan Li, Hong-Mei Li, Duan-Ji Wan, Ya-Jie Tang*. Comparison of lipid content and fatty acid composition between Tuber fermentation mycelia and natural fruiting-bodies. Journal of Agricultural and Food Chemistry 2011, 59:4736-4742.

　　37. Ya-Jie Tang*, Wei Zhang, Rui-Sang Liu, Li-Wen Zhu, Jian-Jiang Zhong. Scale-up study on the fed-batch fermentation of the medicinal mushroom Ganoderma lucidum for the hyperproduction of ganoderic acid and Ganoderma polysaccharides in stirred-tank bioreactor.Process Biochemistry 2011, 46: 404-408.

　　38. Rui-Sang Liu, Ya-Jie Tang*. Tuber melanosporum fermentation medium optimization by Plackett-Burman design coupled with Draper-Lin small composite design and desirability function. Bioresource Technology 2010, 101:3139-3146.

　　39. Rui-Sang Liu, Ya-Jie Tang*. Quantitative analysis for the effect of plant oil and fatty acid on Tuber melanosporum culture by uniform design combined with partial least squares regression.Applied Microbiology and Biotechnology 2010, 87: 1689-1697.

　　40. Li-Wen Zhu, Jian-Jiang Zhong, Ya-Jie Tang*. Multi-fed batch culture integrated with three-stage light irradiation and multiple additions of copper ions for the hyperproduction of ganoderic acid and Ganoderma polysaccharides by the medicinal mushroom Ganoderma lucidum.Process Biochemistry 2010, 45:1904-1911.

　　41. Ya-Jie Tang*, Li-Wen Zhu. Improvement of ganoderic acid and Ganoderma polysaccharide biosynthesis by Ganoderma lucidum fermentation under the inducement of Cu. Biotechnology Progress 2010, 26:417-423.

　　42. Li-Wen Zhu, Ya-Jie Tang*. Significance of protein elicitor isolated from Tuber melanosporum on the production of ganoderic acid and Ganoderma polysaccharides by Ganoderma lucidum.Bioprocess and Biosystems Engineering 2010, 33: 999-1005.

　　43. Ya-Jie Tang*, Xiao-Ling Xu, Jian-Jiang Zhong. A novel biotransformation of 4´-demethylepipodophyllotoxin to 4´-demethylepipodophyllic acid by Bacillus fusiformis CICC 20463, Part II: Process Optimization. Bioprocess and Biosystems Engineering 2010, 33:237-246.

　　44. Qiao-Ning Liu, Rui-Sang Liu, Yi-Hua Wang, Zhi-Yuan Mi, Dong-Sheng Li, Jian-Jiang Zhong, Ya-Jie Tang*. Fed-batch fermentation of Tuber melanosporum for the hyperproduction of mycelia and bioactive Tuber polysaccharides. Bioresource Technology 2009, 100:3644-3649.

　　45. Yan Li, Yuan-Yuan Li, Zhi-Yuan Mi, Dong-Sheng Li, Ya-Jie Tang*. Novel biotransformation process of podophyllotoxin to produce podophyllic acid and picropodophyllotoxin by Pseudomonas aeruginosa CCTCC AB93066, Part II: Process Optimization. Bioresource Technology 2009, 100:2271-2277.

　　46. Ya-Jie Tang*, Wei Zhang, Jian-Jiang Zhong. Performance analyses of a pH-shift and DO-shift integrated fed-batch fermentation process for the production of ganoderic acid and Ganoderma polysaccharides by medicinal mushroom Ganoderma lucidum. Bioresource Technology 2009, 100:1852-1859.

　　47. Ya-Jie Tang*, Guan Wang, Yuan-Yuan Li, Jian-Jiang Zhong. Fermentation condition outweighed truffle species in affecting volatile organic compounds analyzed by chromatographic fingerprint system. Analytica Chimica Acta 2009, 647: 40-45.

　　48. Ya-Jie Tang*, Xiao-Ling Xu, Jian-Jiang Zhong. A novel biotransformation of 4´-demethylepipodophyllotoxin to 4´-demethylepipodophyllic acid by Bacillus fusiformis CICC 20463. Process Biochemistry 2009, 44:572-577.

　　49. Ya-Jie Tang*, Yan Li, Jian-Jiang Zhong. Novel biotransformation process of podophyllotoxin to produce podophyllic acid and picropodophyllotoxin by Pseudomonas aeruginosa CCTCC AB93066, Part I: Process Development. Bioprocess and Biosystems Engineering 2009, 32:663-671.

　　50. Ya-Jie Tang*, Hong-Mei Li, Jean-François P. Hamel. Significance of pH and temperature on the production of heat-shock protein glycoprotein 96 by MethA tumor cell suspension culture in stirred-tank bioreactors. Bioprocess and Biosystems Engineering 2009, 32:267-276.

　　51. Ya-Jie Tang*, Hong-Mei Li, Jean-François P. Hamel. Effect of dissolved oxygen tension and agitation rate on the production of heat-shock protein glycoprotein 96 by MethA tumor cell suspension culture in stirred-tank bioreactors. Bioprocess and Biosystems Engineering 2009, 32:475-484.

　　52. Yuan-Yuan Li, Zhi-Yuan Mi, Yang Tang, Guan Wang, Dong-Sheng Li, Ya-Jie Tang*. Lanostanoids isolated from Ganoderma lucidum mycelium cultured by submerged fermentation. Helvetica Chimica Acta 2009, 92:1586-1593.

　　53. Ya-Jie Tang*, Ling-Li Zhu, Rui-Sang Liu, Hong-Mei Li, Dong-Sheng Li, Zhi-Yuan Mi. Quantitative response of cell growth and Tuber polysaccharides biosynthesis by medicinal mushroom Chinese truffle Tuber sinense to metal ion in culture medium. Bioresource Technology 2008, 99:7606-7615.

　　54. Guan Wang, Yuan-Yuan Li, Dong-Sheng Li, Ya-Jie Tang*. Determination of 5α-androst-16-en-3α-ol in truffle fermentation broth by solid-phase extraction coupled with gas chromatography-flame ionization detector/electron impact mass spectrometry. Journal of Chromatography B 2008, 870:209-215. ( with equal contribution to this work)

　　55. Li-Wen Zhu, Jian-Jiang Zhong, Ya-Jie Tang*. Significance of fungal elicitors on the production of Ganoderma polysaccharides and ganoderic acid by submerged fermentation of medicinal mushroom Ganoderma lucidum. Process Biochemistry 2008, 43:1359-1370.

　　56. Rui-Sang Liu, Dong-Sheng Li, Hong-Mei Li, Ya-Jie Tang*. Response surface modeling the significance of nitrogen source on the cell growth and Tuber polysaccharides production by submerged cultivation of Chinese truffle Tuber sinense. Process Biochemistry 2008, 43:868-876.

　　57. Ya-Jie Tang*, Ling-Li Zhu, Dong-Sheng Li, Zhi-Yuan Mi, Hong-Mei Li. Significance of inoculation density and carbon source on the mycelial growth and Tuber polysaccharides production by submerged fermentation of Chinese truffleTuber sinense. Process Biochemistry 2008, 43:576-586.

　　58. Wei Zhang, Ya-Jie Tang*. A novel three-stage light irradiation strategy in the submerged fermentation of medicinal mushroom Ganoderma lucidum for the efficient production of ganoderic acid and Ganoderma polysaccharides. Biotechnology Progress 2008, 24:1249-1261.

　　59. Ya-Jie Tang*, Li-Wen Zhu, Hong-Mei Li, Dong-Sheng Li. Submerged culture of mushroom in bioreactors - challenges, current state-of-the-art, and future prospects. Food Technology and Biotechnology 2007, 45(3):221-229. (Invited Review)

　　60. Ya-Jie Tang*, Hong-Mei Li, Jean-Francois P. Hamel. Suspension culture process of MethA tumor cell for the production of heat-shock protein glycoprotein 96: process optimization in spinner flasks. Biotechnology Progress2007, 23 (6):1363-1377.

　　61. Ya-Jie Tang*, Ryo Ohashi, Jean-Francois P. Hamel. Perfusion culture of hybridoma cell for hyperproduction of IgG2a monoclonal antibody in a wave bioreactor-perfusion culture system. Biotechnology Progress 2007, 23:255-264.

　　62. Ya-Jie Tang, Jian-Jiang Zhong*. Modeling the kinetics of cell growth and ganoderic acid production in liquid static cultures of medicinal mushroom Ganoderma lucidum. Biochemical Engineering Journal 2004, 21:259-264.

　　63. Ya-Jie Tang, Jian-Jiang Zhong*. Role of oxygen supply in submerged fermentation of Ganoderma lucidum for production of Ganoderma polysaccharide and ganoderic acid. Enzyme and Microbial Technology 2003, 34: 478-484.

　　64. Ya-Jie Tang, Jian-Jiang Zhong*. Scale-up of a liquid static culture process for hyperproduction of ganoderic acid by the medicinal mushroom Ganoderma lucidum. Biotechnology Progress 2003, 19:1842-1846.

　　65. Ya-Jie Tang, Jian-Jiang Zhong*. Exopolysaccharide biosynthesis and related enzyme activities of the medicinal fungus, Ganoderma lucidum, grown on lactose in a bioreactor. Biotechnology Letters 2002, 24: 1023-1026.

　　66. Ya-Jie Tang, Jian-Jiang Zhong*. Fed-batch fermentation of Ganoderma lucidum for hyperproduction of polysaccharide and ganoderic acid. Enzyme and Microbial Technology 2002, 31: 20-28.